Friday, 20 July 2012


Maximum Tolerated Dose (MTD): An animal / human experiment to find the highest dose of a chemical that, when administered to a group of test subjects in a clinical trial, does not result in a fatality due to short-term toxicity. This dose is then used for longer-term safety studies of the same species, lasting anywhere from two years to a lifetime. The MTD test is controversial, however, in part because of difficulties in extrapolating findings to more realistic doses, and in extrapolating results from animals to humans.

Maximum Tolerated Dose is the first feature-length documentary by Decipher Films. Equal parts found-footage mash-up, verité investigation, and artful meditation, the film charts the lives of both humans and non-humans who have experienced animal testing first-hand, with hauntingly honest testimony of scientists and lab technicians whose ethics demanded they choose a different path, as well as the simultaneously heartwarming and heartbreaking stories of animals who have seen both sides of the cage. MTD aims to re-ignite the debate about animal testing by bringing these rarely-heard perspectives to the fore.

Directed by Karol Orzechowski
Edited by Karol Orzechowski & Jonathan Eagan
Produced by Jonathan Hodgson, Jennifer Bundock & Karol Orzechowski
Additional Filming by Jo-Anne McArthur & Guna Subramaniam
With Selected Archival Footage from The BUAV & Igualdad Animal
Music by Wyrd Visions and Bryan W. Bray

on tour now. here are the next batch of dates. Full info at

July 21st, 7 pm: MTD screening @ 2233 w Dickerson road
July 24th, 7 PM – MTD screening @ The Hollywood Theater, 4122 NE Sandy Blvd.
July 27th, 7 PM - Screening of MTD and Q&A @ The Wildcat, 1105 23rd Ave. 
July 31st, 7 pm: MTD screening @ Camas Books, 2590 Quadra Street
Aug 3rd, 7 PM - MTD screening @ Vancouver Public Library, 350 West Georgia


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